发明名称 |
COMBINATION THERAPY FOR BREASTCANCER COMPRISING AN ANTIESTROGENIC AGENT |
摘要 |
<p>This invention relates to combination therapies for the treatment of breast cancer comprising administering to a subject in need thereof a compound of Formula I or a pharmaceutically acceptable salt thereof and an anti-estrogenic agent (e.g., an aromatase inhibitor, a SERM that is not the SERM of Formula I, a GNRH agonist, a GNRH antagonist, or an estrogen receptor downregulator) and to compositions (e.g., pharmaceutical compositions) comprising a compound of Formula I or a pharmaceutically acceptable salt thereof and an anti-estrogenic agent. This invention also relates to a method of treating the side effects (e.g., vasomotor disturbances, osteoporosis and musculoskeletal complaints) associated with anti-estrogen therapy in a subject treated with one or more anti-estrogenic agents (e.g., an aromatase inhibitor, a SERM that is not the SERM of Formula I, a GNRH agonist, a GNRH antagonist or an estrogen receptor downregulator). The method comprises administering to the subject an effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof.</p> |
申请公布号 |
WO2009137104(A1) |
申请公布日期 |
2009.11.12 |
申请号 |
WO2009US02885 |
申请日期 |
2009.05.07 |
申请人 |
RADIUS HEALTH, INC.;LYTTLE, C., RICHARD;HATTERSLEY, GARY;O'DEA, LOUIS |
发明人 |
LYTTLE, C., RICHARD;HATTERSLEY, GARY;O'DEA, LOUIS |
分类号 |
A61K31/137;A61K31/138;A61K31/4196;A61K31/5685;A61P35/00 |
主分类号 |
A61K31/137 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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