Method for producing a recombinant peptide and resultant peptide

摘要

The invention relates to peptides with the following general formula:
A-Thr-Lys-Pro-B-C-D-X, where:
A—0, Met, Met (O), Thr, Ala, His, Phe, Lys, Gly

B—0, Gly, Asp, Trp, Gln, Asn, Tyr, Pro, Arg

C—0, Arg, Phe, Tyr, Gly, His, Pro, Lys

D—0, Val, Gly, Tyr, Trp, Phe, His

X—OH, OCH3, NH2,

where 0 is no amino acid residue, provided that if A≠0, then B and/or C and/or D≠0, if B≠0, then C and/or D≠0,

excluding the peptides Phe-Thr-Lys-Pro-Gly (SEQ ID NO: 1), Thr-Lys-Pro-Pro-Arg (SEQ ID NO: 2), Thr-Lys-Pro-Arg-Gly (SEQ ID NO: 3).

主权项

1. A pharmaceutical composition comprising a peptide consisting of formula:
A-Thr-Lys-Pro-B-C-D-X,wherein:
A is absent, Met, Met(O), Thr, Ala, His, Phe, Lys, Gly; B is absent, Gly, Asp, Trp, Gln, Asn, Tyr, Pro, Arg; C is absent, Arg, Phe, Tyr, Gly, His, Pro; D is absent, Val, Tyr, Trp, Phe, His; X is a carboxy terminal OH, OCH3, or NH2 group,provided that (i) when A is present, at least one of B, C, or D is also present, or when B is present, then C and/or D is also present and (ii) the peptide is not a tetrapeptide and is not Thr-Lys-Pro-X (SEQ ID NO: 5), Phe-Thr-Lys-Pro-Gly-X (SEQ ID NO: 1), Thr-Lys-Pro-Pro-Arg-X (SEQ ID NO: 2), Thr-Thr-Lys-Pro-Arg-X (SEQ ID NO: 607), Lys-Thr-Lys-Pro-Arg-X (SEQ ID NO: 772), Thr-Lys-Pro-Gly-Pro-X (SEQ ID NO: 460), Thr-Lys-Pro-Gly-Arg-X (SEQ ID NO: 456), Thr-Lys-Pro-Arg-Tyr (SEQ ID NO: 494), or Thr-Lys-Pro-Arg-Gly-X (SEQ ID NO: 3), wherein said peptide is present in the composition in an amount effective for stimulating sexual or reproductive function.