发明名称 |
OPHTHALMIC DEVICE, AND METHOD OF USE THEREOF, FOR INCREASING OCULAR BOUNDARY LUBRICATION |
摘要 |
The present invention provides an ophthalmic device, and method of use thereof, for an individual wearing an ophthalmic lens to increase ocular surface boundary lubrication. The invention device comprises an ophthalmic lens and a sacrificial mechanism disposed on the ophthalmic lens, wherein the sacrificial mechanism comprises a plurality of surface bound receptors, such as PRG4, hyaluronic acid, and DNA aptamers, that reversibly bound to a lubricating composition comprising a gel forming agent, a surfactant, or a combination thereof, effectively inhibiting or preventing protein and lipid adsorption on the surface of the lens, and mitigate shear stress and reduce the friction between the lens and the ocular surface of the individual in need. |
申请公布号 |
WO2009137603(A1) |
申请公布日期 |
2009.11.12 |
申请号 |
WO2009US43018 |
申请日期 |
2009.05.06 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;SULLIVAN, BENJAMIN;SCHMIDT, TANNIN, A.;SULLIVAN, DAVID, A.;SCHEPENS EYE RESEARCH INSTITUTE |
发明人 |
SULLIVAN, BENJAMIN;SCHMIDT, TANNIN, A.;SULLIVAN, DAVID, A. |
分类号 |
A61K31/715;A61K36/00;A61K38/16 |
主分类号 |
A61K31/715 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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