Base modified oligonucleotides

摘要

The present invention relates to oligonucleotides with base modified nucleosides for enhancement of binding affinity.

主权项

1. A base modified antisense oligonucleotide, comprising: at least one nucleotide having both:
a) a 2′ modification; and b) an amino carbonyl base modification at the C-5 position of a pyrimidine base, wherein the oligonucleotide is from about 5 to about 25 nucleotides in length and contains one or more phosphorothioate linkages; and wherein the 2′ modification is 2′-OMe and the amino carbonyl modified pyrimidine base has the following structure: wherein R is at least one member selected from the group consisting of: