发明名称 |
METHOD FOR TREATMENT OR PREVENTION OF DISEASE ASSOCIATED WITH FUNCTIONAL DISORDER OF REGULATORY T CELL |
摘要 |
The inventors examined the role of MK in experimental autoimmune encephalomyelitis, which is a human model for multiple sclerosis. As a result, they discovered that MK has the effect of inhibiting regulatory T cells, and that the autoimmune mechanism induced by type 1 helper T cells can be suppressed by inhibiting MK expression or its activity, thereby increasing the number of regulatory T cells. Furthermore, it was found that diseases associated with the functional disorder of regulatory T cells can be treated with the administration of an inhibitor that inhibits MK expression or activity. |
申请公布号 |
EP1964574(A4) |
申请公布日期 |
2009.11.11 |
申请号 |
EP20060832616 |
申请日期 |
2006.11.14 |
申请人 |
MEDICAL THERAPIES LIMITED;RIBOMIC INC |
发明人 |
SUZUMURA, AKIO;WANG, JINYAN;MATSUI, TAKASHI;SAKUMA, SADATOSHI;MIYAKAWA, SHIN;FUJIWARA, MASATOSHI;NAKAMURA, YOSHIKAZU |
分类号 |
A61K45/00;A61K31/7105;A61K31/711;A61K39/395;A61P25/00;A61P29/00;A61P37/02;A61P43/00;C12Q1/04;C12Q1/68;G01N33/15;G01N33/50 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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