发明名称 |
METHOD OF TREATING PATIENTS SUFFERING FROM COLORECTAL CANCER WITH LIVER METASTASES |
摘要 |
FIELD: medicine. ^ SUBSTANCE: invention concerns medicine, namely oncology and can be used in treatment of patients with colorectal cancer with multiple liver metastases. The first stage of treatment involves neoadjuvant oxalyplatine chemotherapy; in addition Tomudex is introduced in a dose 3 mg/m2 as a 24 hour continuous infusion. After termination of chemotherapy, biotherapy involves intra-arterial injection of Avastin in a dose 10 mg/kg of body weight within 2 hours, neoadjuvant intra-arterial chemotherapy and biotherapy totals in 4-6 courses. At the second stage 4 weeks after chemotherapy surgery is performed. The third stage involves 4-6 courses of adjuvant intra-arterial chemotherapy and biotherapy, as at the first stage. ^ EFFECT: invention allows increasing survival rate and life expectancy of the patients owing to improved respectability of metastases and lower toxicity of complex neoadjuvant and adjuvant intra-arterial chemotherapy and biotherapy. ^ 1 ex |
申请公布号 |
RU2372089(C2) |
申请公布日期 |
2009.11.10 |
申请号 |
RU20070149399 |
申请日期 |
2007.12.26 |
申请人 |
GOSUDARSTVENNOE OBRAZOVATEL'NOE UCHREZHDENIE VYSSHEGO PROFESSIONAL'NOGO OBRAZOVANIJA "ALTAJSKIJ GOSUDARSTVENNYJ MEDITSINSKIJ UNIVERSITET FEDERAL'NOGOAGENTSTVA PO ZDRAVOOKHRANENIJU I SOTSIAL'NOMU RAZVITIJU" (GOU VPO AGMU ROSZDRAVA) |
发明人 |
LAZAREV ALEKSANDR FEDOROVICH;PATJUTKO JURIJ IVANOVICH;SHOJKHET JAKOV NAUMOVICH;KOTEL'NIKOV ALEKSEJ GENNAD'EVICH;KARPENKO ANDREJ ANATOL'EVICH;MAMONTOV KONSTANTIN GRIGOR'EVICH;IGITOV VLADIMIR IVANOVICH;BELONOZHKA ANATOLIJ VASIL'EVICH;PONOMARENKO ALEKSEJ ALEKSEEVICH;DOROSHENKO VERONIKA SERGEEVNA;PORUNOV VJACHESLAV JUR'EVICH;ELINOV ALEKSANDR PETROVICH |
分类号 |
A61K31/282;A61K31/517;A61K39/395;A61P35/00 |
主分类号 |
A61K31/282 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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