发明名称 |
4-aminopyrimidine-5-one derivatives |
摘要 |
Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.
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申请公布号 |
US7615634(B2) |
申请公布日期 |
2009.11.10 |
申请号 |
US20060471001 |
申请日期 |
2006.06.20 |
申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
BARTKOVITZ DAVID JOSEPH;CHU XIN-JIE;DING QINGJIE;JIANG NAN;LOVEY ALLEN JOHN;MOLITERNI JOHN ANTHONY;MULLIN, JR. JOHN GUILFOYLE;VU BINH THANH;WOVKULICH PETER MICHAEL |
分类号 |
C07D239/47;C07D239/46;C07D239/48;C07D401/12;C07D401/14;C07D403/12;C07D403/14;C07D405/12;C07D405/14;C07D409/06;C07D409/12;C07D409/14;C07D413/14 |
主分类号 |
C07D239/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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