摘要 |
<p>Provided are spherical granules, which have been improved in abrasiveness and granular hardness each to a sufficiently high level and have a high sphericity and, in the case of being surface-coated with a physiologically active substance or the like and employed in a medicinal preparation, which show an excellent ability to control the release of the physiologically active substance; and a method whereby the above-described spherical granules can be efficiently and conveniently produced. A method of producing spherical granules characterized by comprising while tumbling sugar-containing core grains by rotating a rotary plate that is located horizontally, spraying a liquid containing solid matters onto the core grains without dusting a powdery component. Preferred are a mode wherein the above-described liquid is an aqueous solution or suspension containing a sugar, a mode wherein the above-described core grains contain sugar crystals or spray-dried grains of a sugar, starch of a derivative of the same, and a mode wherein an aqueous solution containing a sugar and/or a sugar alcohol is further sprayed onto the surface of the spherical granules obtained above to thereby form a surface coating layer. Spherical granules characterized by being produced by the above-described method of producing spherical granules.</p> |