<p>The present invention provides novel tubulysin analogues, methods of making and methods of using such analogues and conjugates thereof. The compounds of the invention are highly potent cell-growth inhibitors have been developed that are smaller and considerably more stable than tubulysin D.</p>
申请公布号
WO2009134279(A1)
申请公布日期
2009.11.05
申请号
WO2008US70677
申请日期
2008.07.21
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;ELLMAN, JONATHAN, A.;PATTERSON, ANDREW, W.;PELTIER, HILLARY