INHIBITORS OF BIOFILM FORMATION OF GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA
摘要
The present invention relates to the use of compounds as broad spectrum inhibitors of bacterial biofilm formation. In particular the invention refers to a family of compounds that block the quorum sensing system of Gram-negative and Gram-positive bacteria, a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of bacterial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens.
申请公布号
WO2009077844(A3)
申请公布日期
2009.11.05
申请号
WO2008IB03496
申请日期
2008.12.15
申请人
QUONOVA LLC;AMMENDOLA, ALDO;WIEBER, TANJA;WUZIK, ANDREAS;LANG, MARTIN
发明人
AMMENDOLA, ALDO;WIEBER, TANJA;WUZIK, ANDREAS;LANG, MARTIN