| 发明名称 |
CHRONOTHERAPEUTIC ANTI-HYPERTENSIVE FORMULATIONS OF MODIFIED-RELEASE CALCIUM CHANNEL BLOCKER |
| 摘要 |
<p>The present invention relates to formulations of anti-hypertensive drugs. The present invention includes a modified-release formulation of diltiazem hydrochloride that is suitable for once-daily use and which provides delivery of drug either in the early morning hours, or overnight, so as to blunt the natural rise in blood pressure (BP) and heart rate (HR) in the morning and to reduce the slope of the increase in BP in patients with elevated BP (hypertension).</p> |
| 申请公布号 |
WO2009134956(A1) |
申请公布日期 |
2009.11.05 |
| 申请号 |
WO2009US42210 |
申请日期 |
2009.04.30 |
| 申请人 |
BLUE NOTE PHARMACEUTICALS, INC. |
发明人 |
PETTI, STEPHEN, J.;RAFFANIELLO, SAMN |
| 分类号 |
A61K9/22;A61K9/24 |
主分类号 |
A61K9/22 |
| 代理机构 |
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