SYNTHESIS OF DESACETOXYTUBULYSIN H AND ANALOGS THEREOF

摘要

Compounds of formula I, XVI and XXI possess potent cell growth inhibitory activity. These compounds are described have therapeutic utility, particularly in the treatment of cancer as well as conditions and disorders related to uncontrolled cell growth wherein the variables R1, R2, R3, R4, R5, X, Y and Z are described herein.