发明名称 |
Transition metal mediated oxidation of hetero atoms in organic molecules coordinated to transition metals |
摘要 |
The present invention is directed to a process for the catalytic oxidation of the thioether 5-methoxy-2-((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)methylthio)-1H-benzimidazole to its sulfoxide: 5-methoxy-2-((4-methoxy-3,5-dimethyl-2-pyridinyl) methyl)methylsulfinyl)-1H-benzimidazole comprising: reacting the thioether with: 1) a transition metal catalyst; and, 2) an oxygen source; wherein the thioether is oxidized to a sulfoxide and wherein one of either the R and S enantiomers is formed to an enantiomeric excess.
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申请公布号 |
US2009274755(A1) |
申请公布日期 |
2009.11.05 |
申请号 |
US20090459757 |
申请日期 |
2009.07.07 |
申请人 |
WHEELOCK KENNETH S;PICCONE LOUIS A |
发明人 |
WHEELOCK KENNETH S.;PICCONE LOUIS A. |
分类号 |
A61K9/48;A61K9/00;A61K31/4439;C07D401/02 |
主分类号 |
A61K9/48 |
代理机构 |
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地址 |
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