MEDICAL DEVICES HAVING BIOERODABLE LAYERS FOR THE RELEASE OF THERAPEUTIC AGENTS

摘要

According to an aspect of the present invention, medical devices are provided which comprise: (a) a substrate, (b) an inner bioerodable polymeric layer over the substrate that comprises (i) 80 wt% or more of an amorphous biodegradable polymeric component and (ii) 20 wt% or less of a therapeutic agent component, and (c) an outer bioerodable polymeric layer over the inner bioerodable polymeric layer that comprises (i) 80 wt% or more of an amorphous biodegradable polymeric component and (ii) 20 wt% or less of a therapeutic agent component. The compositions of the inner and outer layers differ such that the outer layer has a bioerosion rate that is faster than that of the inner layer.