| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide recombinant viruses selectively replicating a viral genome corresponding to the intracellular conditions of a target cell through use of a pathway-responsive promotor substantially inhibiting viral replication in host cells based on the phenotype or genotype of infected cells. <P>SOLUTION: In the target cell, the promotor element of the pathway-responsive promotor is inactive, and therefore, the virus is able to be replicated. This results in: (1) killing the cells by lytic nature of the virus, and/or (2) providing a therapeutic dose of a transgene product to the target cell, and (3) producing a localized concentration of the virus facilitating the infection of surrounding cells by the recombinant virus. Pharmaceutical formulations, methods for preparing the vectors and transformed cells comprising the vectors are also provided. <P>COPYRIGHT: (C)2010,JPO&INPIT |
