发明名称 |
Tight Junction Modulating Peptides for Enhanced Mucosal Delivery of Therapeutic Compounds |
摘要 |
Compositions and methods are provided that include a biologically active agent and a permeabilizing agent effective to enhance mucosal delivery of the biologically active agent in a mammalian subject, in which the permeabilizing peptide is a tight junction modulating peptide (TJMP), a TJMP analogue, a conjugate of a TJMP, a conjugate of a TJMP analogue, or complexes thereof. The permeabilizing agent reversibly enhances mucosal epithelial paracellular transport, typically by modulating epithelial junctional structure and/or physiology at a mucosal epithelial surface in the subject. |
申请公布号 |
US2009274658(A1) |
申请公布日期 |
2009.11.05 |
申请号 |
US20090480519 |
申请日期 |
2009.06.08 |
申请人 |
NASTECH PHARMACEUTICAL COMPANY, INC. |
发明人 |
CUI KUNYUAN;QUAY SHU-CHIH CHEN;FRY KRISTINE T. |
分类号 |
A61K38/21;A61K38/18;A61K47/42;C07K7/00 |
主分类号 |
A61K38/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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