发明名称 |
7-Polyaminoalkyl(oxy)iminomethylcamptothecins bearing protective groups |
摘要 |
Compounds are disclosed with the general formula in which the groups are as defined in the description here below and characterized by the presence of polyamine substituents on the imine/oxime residue, such amine groups being in turn protected by suitable protective groups. Said compounds are endowed with potent topoisomerase I inhibiting activity and therefore are useful as medicaments for the treatment of tumors and viral and parasite infections.
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申请公布号 |
US7612081(B2) |
申请公布日期 |
2009.11.03 |
申请号 |
US20040564637 |
申请日期 |
2004.07.06 |
申请人 |
ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI;SIGMA TAU INDUSTRIE FARVACEUTICHE RIUNITE S.P.A. |
发明人 |
GIANNINI GIUSEPPE;PISANO CLAUDIO;VESCI LOREDANA;TINTI MARIA ORNELLA;MERLINI LUCIO;PENCO SERGIO;ZUNINO FRANCO |
分类号 |
A61K31/4745;A61K31/437;A61P35/00;C07D491/00;C07D491/22 |
主分类号 |
A61K31/4745 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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