发明名称 2,6,9-substituted purine derivatives and their use in the treatment of proliferative disorders
摘要 The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof wherein R2 is 2-hydroxymethylpyrrolidin-1-yl, or NHCH(R4)CH(R3)OH, wherein R3 is hydrogen or methyl and R4 is methyl, ethyl or isopropyl; R6 is 3-nitrophenylamino, 3,4-dimethoxybenzylamino, 3-iodobenzyl-amino, pyrid-2-yl-methylamino, pyrid-4-yl-methylamino or indan-5-amino; R9 is isopropyl or cyclopentanyl. In a further aspect, the invention relates to pharmaceutical compositions comprising said compounds, and the use thereof in treating antiproliferative disorders and or viral disorders.
申请公布号 US7612079(B2) 申请公布日期 2009.11.03
申请号 US20030742237 申请日期 2003.12.18
申请人 CYCLACEL LIMITED;CANCER RESEARCH TECHNOLOGY LIMITED 发明人 FISCHER PETER MARTIN;JARMAN MIKE;MCDONALD TED;NUTLEY BERNARD;RAYNAUD FLORENCE;WILSON STUART;WORKMAN PAUL
分类号 C07D473/16;A61K31/52;A61P17/06;A61P25/28;A61P31/12;A61P35/00;A61P35/02;A61P43/00;C07C215/08 主分类号 C07D473/16
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