发明名称 |
Melanoma antigens and their use in diagnostic and therapeutic methods |
摘要 |
The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess or prognoses a mammal afflicted with melanoma or metastata melanoma. This invention also provides immunogenic peptides derived from the MART-1 melanoma antigen and a second melanoma antigen designated gp100. This invention further provides immunogenic peptides derived from the MART-1 melanoma antigen or gp100 antigen which have been modified to enhance their immunogenicity. The proteins and peptides provided can serve as an immunogen or vaccine to prevent or treat melanoma.
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申请公布号 |
US7612044(B2) |
申请公布日期 |
2009.11.03 |
申请号 |
US20070751233 |
申请日期 |
2007.05.21 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
KAWAKAMI YUTAKA;ROSENBERG STEVEN A. |
分类号 |
A01K67/027;A61K38/00;A61K39/00;A61K39/395;A61P35/00;A61P37/04;C07K5/00;C07K14/47;C07K14/82;C07K16/32;C12N5/10;C12N15/09;C12P21/02;C12P21/08;C12Q1/68;G01N33/53;G01N33/574;G01N33/577 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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