发明名称 |
METHOD FOR SEPARATION OF INTERMEDIATES WHICH MAY BE USED FOR THE PREPARATION OF ESCITALOPRAM |
摘要 |
The invention relates to a method of separating and isolating an acylated derivative of 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxymethylbenzonitrile by reaction of a mixture of the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3-hydroxymethylbenzonitrile and an acylated derivative thereof with a compound which form a derivative of the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3-hydroxymethylbenzonitrile containing a carboxylic acid group. The acylated derivative containing a carboxylic acid group precipitates once it is formed and may easily be separated from the reaction mixture. |
申请公布号 |
EA012503(B1) |
申请公布日期 |
2009.10.30 |
申请号 |
EA20060001469 |
申请日期 |
2005.02.02 |
申请人 |
H. LUNDBECK A/S |
发明人 |
LYNGSO LARS, OLE |
分类号 |
C07C253/34;C07B57/00;C07C253/30;C07C255/53;C07C255/59;C07D307/87 |
主分类号 |
C07C253/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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