Quinoline derivatives for inhibiting amyloid deposits

摘要

Disclosed is the use of a compound selected from: 8-hydroxy-5-quinolinesulfonic acid,8-hydroxy-7-iodo-5-quinolinesulfonic acid, 5-chloro-8-quinolylmethylsulfonic acid, 5,8-dibromo-6-quinolylmethylsulfonic acid, 8-ethoxy-5-quinolinesulfonic acid, 5-chloro-6-quinolylmethylsulfonic acid, quinoline yellow, 5-bromo-6-quinolylmethylsulfonic acid, 7-bromo-8-hydroxy-5-quinolinesulfonic acid, 7-chloro-8-hydroxy-5-quinolinesulfonic acid, 5-chloro-8-hydroxy-7-quinolinesulfonic acid, 5-bromo-8-hydroxy-7-quinolinesulfonic acid, 8-hydroxy-2-methyl-5-quinolinesulfonic acid, 8-hydroxy-2-methyl-5,7-quinolinedisulfonic acid, 5-chloro-8-hydroxy-2-methyl-7-quinolinesulfonic acid, 5-bromo-8-hydroxy-2-methyl-7-quinolinesulfonic acid, 2,6-quinolyldimethyldisulfonic acid, 5-chloro-2,6-quinolyldimethyldisulfonic acid, 8-methoxy-5-quinolinesulfonic acid, 8-methoxy-5-[N-(2-N',N'-diethylethylamino)]quinolinesuIfonamide, 8-methoxy-5-[N-(2-N',N'-indoIineethylamino)]quinolinesulfonamide, and 4-[2-( 1,2,3,4,5,6,7,8-octahydroisoquinolinyl)]-1-butanesulfonic acid, or a pharmaceutically acceptable ester, acid or salt thereof, to treat a disease state characterized by lAPP-associated amyloid deposits, such as in the pancreatic islets.