METHODS FOR THE PRODUCTION OF ANSAMITOCINS

摘要

The invention relates to processes of the large-scale fermentation of a highly productive ansamitocin-producing strains. Methods are provided for culturing a microorganism highly productive for ansamitocins in a liquid culture medium in large fermenters. Methods are also provided for the extraction of the ansamitocin from the culture broth and the microorganism into a non- aromatic water-immiscible organic solvent in which the ansamitocin is highly soluble. The invention provides a need of ansamitocin production in industrial scale in high yields and also to provide an efficient process for its isolation and purification, while minimizing worker exposure to the highly toxic drug.