Anti-ADDL antibodies and uses thereof

摘要

Disclosed is an antibody that differentially recognizes multi-dimensional conformations of Abeta-derived diffusible ligands, also known as ADDLs. The antibody can distinguish between Alzheimer's Disease and control human brain extracts and is useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The antibody can also block binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and is useful in methods for preventing and treating diseases associated with soluble oligomers of amyloid beta 1-42.