Combination therapy for the treatment of ocular neovascular disorders using a PDGF antagonist and a VEGF antagonist

摘要

Disclosed is a pharmaceutical composition comprising: (i) a PDGF antagonist; (ii) a VEGF antagonist; and (iii) a pharmaceutically acceptable carrier, wherein the PDGF antagonist is a nucleic acid molecule, an aptamer, an antisense RNA molecule, a ribozyme, or an RNAi molecule, the VEGF antagonist is an antibody or antibody fragment, and the PDGF antagonist and the VEGF antagonist are present in an amount sufficient to suppress a neovascular disorder in a patient.