Solid dosage form comprising proton pump inhibitor and suspension made thereof

摘要

Disclosed is an oral pharmaceutical dosage form being a solid rapidly gelling granulate mixture, suitable for making a suspension comprising I) an acid sensitive proton pump inhibitor as active ingredient distributed in a multitude of enteric coated pellets and II) a granulate, characterised in that the granulate is a suspension modifying granulate comprising a rapidly dissolving diluent chosen from mono- and disaccharides and hydrates thereof, but not mannitol, randomly distributed in and on the individual granule particles, a gelling agent chosen among xanthan gums, an acidic pH-regulating agent chosen among citric acid, tartaric acid and malic acid, a binder and an optional disintegrant wherein the ratio between the binder and an optional disintegrant and the granulate is free from bicarbonate salts and carbonate salts and wherein the ratio between the binder and the gelling agent in the suspension modifying granulate is from 1:2 to 1:3, w/w.