PYRROLIDINES AND THIAZOLIDINES DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA AND OF TYPE II DIABETIS

摘要

COMPOUND OF FORMULA (&Igr;): WHEREIN: • X1 REPRESENTS AN ATOM OR GROUP SELECTED FROM CR4AR4B, O, S(O)Q1 AND NR5, WHEREIN R4A, R4B, Q1 AND R5 ARE AS DEFINED IN THE DESCRIPTION, • M1 REPRESENTS ZERO OR AN INTEGER OF FROM 1 TO 4 INCLUSIVE, • M2 REPRESENTS AN INTEGER OF FROM 1 TO 4 INCLUSIVE, • N1 AND N2, WHICH MAY BE IDENTICAL OR DIFFERENT, EACH REPRESENT AN INTEGER OF FROM 1 TO 3 INCLUSIVE, • R1 REPRESENTS A HYDROGEN ATOM OR A GROUP SELECTED FROM CARBOXY, ALKOXYCARBONYL, OPTIONALLY SUBSTITUTED CARBAMOYL AND OPTIONALLY SUBSTITUTED ALKYL, • R2 REPRESENTS A HYDROGEN ATOM OR AN ALKYL GROUP, • AK REPRESENTS AN OPTIONALLY SUBSTITUTED ALKYLENE CHAIN, • P REPRESENTS ZERO, 1 OR 2, • R3 REPRESENTS A HYDROGEN ATOM OR A CYANO GROUP, • X2 AND X3, WHICH MAY BE IDENTICAL OR DIFFERENT, EACH REPRESENT EITHER A S(O)Q2 OU OF A CR6AR6B GROUP, WHEREIN Q2, R6A AND R6B ARE AS DEFINED IN THE DESCRIPTION, ITS OPTICAL ISOMERS, WHERE THEY EXIST, AND ITS ADDITION SALTS WITH A PHARMACEUTICALLY ACCEPTABLE ACID. MEDICAMENTS.