| 发明名称 |
Anti-VEGF antibodies with high affinity for binding to VEGF |
| 摘要 |
Disclosed is an antibody, or a Fab fragment thereof, capable of binding to mouse VEGF and human VEGF with Kd values within 10 fold of the other, wherein the antibody contacts no more than 80% of the surface area of G88 of human VEGF and wherein the antibody is capable of inhibiting the binding of VEGF to a VEGF receptor. |
| 申请公布号 |
NZ545135(A) |
申请公布日期 |
2009.10.30 |
| 申请号 |
NZ20040545135 |
申请日期 |
2004.07.30 |
| 申请人 |
GENENTECH, INC. |
发明人 |
FUH, GERMAINE;GERBER, HANSPETER;LIANG, WEI-CHING;FELLOUSE, FREDERIC A;SIDHU, SACHDEV S;WIESMANN, CHRISTIAN |
| 分类号 |
C07K16/00;A61P35/00;C07H21/04;C07K14/705;C07K16/22;C07K16/32;C12N15/13;C12N15/62;C12P21/04 |
主分类号 |
C07K16/00 |
| 代理机构 |
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代理人 |
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