| 摘要 |
THE PRESENT INVENTION PROVIDES ANTIBODIES, AND ANTIGEN-BINDING FRAGMENTS OF ANTIBODIES, FUSION POLYPEPTIDES AND ANALOGS THAT PREFERENTIALLY BIND CELL-ASSOCIATED CA 125/O772P POLYPEPTIDES RELATIVE TO SHED CA 125/O772P POLYPEPTIDES. THE PRESENT INVENTION FURTHER PROVIDES METHODS OF PREVENTING, MANAGING, TREATING OR AMELIORATING ONE OR MORE SYMPTOMS ASSOCIATED WITH CA 125/O772P-RELATED DISORDER. IN PARTICULAR, THE PRESENT INVENTION PROVIDES METHODS OF PREVENTING, MANAGING, TREATING, OR AMELIORATING ONE OR MORE SYMPTOMS ASSOCIATED WITH A CELL PROLIFERATIVE DISORDER, SUCH AS CANCER, E.G., OVARIAN CANCER. THE PRESENT INVENTION STILL FURTHER PROVIDES METHODS FOR DIAGNOSING A CA 125/O772P-RELATED DISORDER OR PREDISPOSITION TO DEVELOPING SUCH A DISORDER, AS WELL AS METHODS FOR IDENTIFYING ANTIBODIES, AND ANTIGEN-BINDING FRAGMENTS OF ANTIBODIES, THAT PREFERENTIALLY BIND CELL-ASSOCIATED CA 125/O772P POLYPEPTIDES RELATIVE TO SHED CA 125/O772P POLYPEPTIDES. |
