发明名称 |
Process for the Selection of HIV-1 Subtype C Isolates, Selected HIV-1 Subtype Isolates, Their Genes and Modifications and Derivatives Thereof |
摘要 |
Embodiments of the invention provide processes for the selection of HIV-1 subtype (clade) C isolates, selected HIV-1 subtype C isolates, their genes and modifications and derivatives thereof for use in prophylactic and therapeutic vaccines to produce proteins and polypeptides for the purpose of eliciting protection against HIV infection or disease. A process for the selection of HIV subtype isolates comprises the steps of isolating viruses from recently infected subjects; generating a consensus sequence for at least part of at least one HIV gene by identifying the most common codon or amino acid among the isolated viruses; and selecting the isolated virus or viruses with a high sequence identity to the consensus sequence. HIV-1 subtype C isolates, designated Du422, Du 151 and Du 179 (assigned Accession Numbers 01032114, 00072724 and 00072725, respectively, by the European Collection of Cell Cultures) are also provided.
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申请公布号 |
US2009270488(A1) |
申请公布日期 |
2009.10.29 |
申请号 |
US20090357099 |
申请日期 |
2009.01.21 |
申请人 |
JOHNSTON ROBERT EDWARD;KARIM SALIM ABDOL;MORRIS LYNN;SWANSTROM RONALD;WILLIAMSON CAROLYN |
发明人 |
JOHNSTON ROBERT EDWARD;KARIM SALIM ABDOL;MORRIS LYNN;SWANSTROM RONALD;WILLIAMSON CAROLYN |
分类号 |
A61K31/7088;C07H21/02;C07H21/04;C07K14/005 |
主分类号 |
A61K31/7088 |
代理机构 |
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