发明名称 |
METHODS OF ALTERING BONE GROWTH BY ADMINISTRATION OF SOST OR WISE ANTAGONIST OR AGONIST |
摘要 |
The present invention provides a method of promoting local bone growth by administering a therapeutic amount of a Sost antagonist to a mammalian patient in need thereof. Preferably, the Sost antagonist is an antibody or FAB fragment selectively recognizing any one of SEQ ID NOS: 1-23. The Sost antagonist may be coadministered together or sequentially with a matrix conducive to anchoring new bone growth. Orthopedic and periodontal devices comprising an implantable portion adapted to be permanently implanted within a mammalian body and bearing an external coating of a Sost antagonist are also disclosed, as it a method of increasing bone density by administering to a mammalian patient a therapeutic amount of a Sost antagonist together with an antiresorptive drug. |
申请公布号 |
WO2009131553(A2) |
申请公布日期 |
2009.10.29 |
申请号 |
WO2007US88542 |
申请日期 |
2007.12.21 |
申请人 |
OSTEOGENEX INC.;ELLIES, DEBRA, L. |
发明人 |
ELLIES, DEBRA, L. |
分类号 |
A61K31/59;A61K38/18;A61K39/395;A61K45/06;A61L27/12;A61L27/54;A61P19/08 |
主分类号 |
A61K31/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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