摘要 |
<p>Disclosed is a stable metastin derivative having excellent biological activities (e.g., a cancer metastasis-inhibiting activity, a cancer proliferation-inhibiting activity, a gonadotropin secretion-promoting activity, a sex hormone secretion-promoting activity). In the metastin derivative, a amino acid residue constituting a metastin moiety is replaced by a specific amino acid residue, so that the stability in the blood and the solubility of the metastin derivative can be further improved, the gelatinization tendency of the metastin derivative can be reduced, the pharmacokinetics of the metastin derivative can be improved, and the metastin derivative can exhibit an excellent cancer metastasis-inhibiting activity and an excellent cancer proliferation-inhibiting activity. The metastin derivative can also exhibit a gonadotropin secretion-inhibiting activity, a sex hormone secretion-inhibiting activity and others.</p> |