| 摘要 |
<p>Pyrrolopyrimidine compounds (I) and their stereoisomers, salts or metabolites, are new. Pyrrolopyrimidine compounds of formula (I) and their stereoisomers, salts or metabolites, are new. X, Y 1>a bond, -O-, -S-, -(C=O)-, -O(C=O)- or -(C=O)-O-; n : 0 or 1; R 1>, R 2>H, pyridyl, pyridyl substituted with F, Cl, Br, I or 1-4C-alkyl, phenyl, or phenyl substituted with carbamoyl-methoxy, carboxy-methoxy, benzyloxycarbonylmethoxy, 1-4C-alkoxycarbonyl-methoxy, phenyl, amino, 1-4C-alkanoylamino, 1-4C-alkylamino, N,N-di-1-4C-alkylamino, OH, 1-4C-alkanoyloxy, carboxyl, 1-4C-alkoxycarbonyl, carbamoyl, N-1-4C-alkyl-carbamoyl, N,N-di-1-4C-alkyl-carbamoyl, CN, or with nitro, N-benzyl-pyridinium-2-yl, naphthyl, 1-4C-alkoxycarbonyl, N-1-4C-alkyl-carbamoyl, N-N-di-1-4C-alkyl-carbamoyl, N-benzylcarbamoyl, formyl, 1-4C-alkanoyl, 1-4C-alkenyl, 1-4C-alkenyloxy, 1-4C-alkyl, 1-4C-alkyl substituted with F, Cl, Br, I, aminopiperazino, di-1-4C-alkylamino, phenylamino, substituted phenyl amino, or 1-4C-alkyl-S(O) z-; z : 0-2; R 3>H, 1-4C-alkyl, 1-4C-alkoxycarbonyl, carbamoyl, N-1-4C-carbamoyl or N,N-di-1-4C-alkyl-carbamoyl; and R 4>H, F, Cl, Br, I, 1-4C-alkyl, OH, 1-4C-alkanoyloxy, 1-4C-alkoxy, carboxyl, 1-4C-alkoxycarbonyl, carbamoyl, N-1-4C-carbamoyl or N,N-di-1-4C-alkyl-carbamoyl, cyano, amino, 1-4C-alkanoylamino, 1-4C-alkylamino, N,N-di-1-4C-alkylamino or trifluoromethyl (all are 1-3 times substituted). Where at least one of the group X or Y 1>is not a bond. An independent claim is included for a pharmaceutical composition comprising (I), optionally an auxiliary material and/or carrier materials. [Image] ACTIVITY : Cytostatic; Antiinflammatory; Antiasthmatic; Antiallergic; Ophthalmological; Dermatological; Antiarthritic; Osteopathic; Gastrointestinal-Gen.; Antibacterial; Immunosuppressive; Antidiabetic; Hemostatic; Neuroprotective; Muscular-Gen.; Antipsoriatic; Nephrotropic; Respiratory-Gen.; Anabolic; Anorectic; Cardiant. MECHANISM OF ACTION : Epidermal growth factor receptor tyrosine kinase inhibitor.</p> |
