METHOD OF UTILIZATION OF COMBINATION OF BENZOPHENONE DERIVATIVE OR SALT THEREOF AND IMMUNOSUPPRESSING AGENT, AND PHARMACEUTICAL COMPOSITION COMPRISING THESE COMPONENTS

摘要

Disclosed are: a method of utilizing a combination of a benzophenone derivative represented by general formula [wherein R1 represents a heterocyclic group which may be substituted, a phenyl group which may be substituted, or the like; Z represents an alkylene group, or the like; R2 represents a carboxyl group which may be protected with an alkyl group, or the like; R3 represents a hydroxyl group which may be protected, or the like; R4 represents a cycloalkyloxy group which may be substituted, or the like; and R5 represents a hydrogen atom, or the like] or a salt thereof and at least one immunosuppressing agent; and a pharmaceutical composition comprising the benzophenone derivative or a salt thereof and at least one immunosuppressing agent. The method and the pharmaceutical composition are useful for the treatment (e.g., therapy and prophylaxis) of autoimmune diseases.