VIRAL INACTIVATION USING CROSSLINKERS AND DETERGENTS

摘要

The invention involves inactivation of viral populations by treating the viral populations with a hydrophobic, photoactivatable crosslinking agent to crosslink proteins in the viral membrane, UV irradiation and further inactivation of the viruses using detergent(s). According to the invention, this method preserves the native structure of viral epitopes so that the inactivated viral preparations can be used in immunological compositions that will inhibit and/or prevent viral infection when administered to an animal.