METHOD OF PRODUCING TABLET, METHOD OF PRODUCING GRANULE AND EQUIPMENT OF PRODUCING GRANULE

摘要

<P>PROBLEM TO BE SOLVED: To provide a method of producing a granule for tableting and tablet, excellent in dispersion uniformity of mixed material powder, controlling at higher accuracy than accuracy by visual observation of an operator, and improving yield. Ž<P>SOLUTION: The method comprises performing a mixing step, a granulating step and a drying step by using a fluidized bed-rolling granulating device, and, before the granulating step, adding a liquid binder containing moisture to increase the moisture content of the mixed material powder in the fluidized bed-rolling granulating device to a value introduced from the preliminary verification results, then, granulating in the fluidized bed rolling granulating device to form an intermediate granule while maintaining the moisture content, and then tableting the intermediate granule. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž