发明名称 |
AZACYCLOALKANE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE |
摘要 |
Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
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申请公布号 |
US2009270434(A1) |
申请公布日期 |
2009.10.29 |
申请号 |
US20090498476 |
申请日期 |
2009.07.07 |
申请人 |
LEBLANC YVES;POWELL DAVID;RAMTOHUL YEEMAN K;LEGER SERGE |
发明人 |
LEBLANC YVES;POWELL DAVID;RAMTOHUL YEEMAN K.;LEGER SERGE |
分类号 |
A61K31/506;A61P3/10;C07D401/14 |
主分类号 |
A61K31/506 |
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