DIAGNOSTIC METHODS FOR PAIN SENSITIVITY AND CHRONICITY AND FOR TETRAHYDROBIOPTERIN-RELATED DISORDERS
摘要
Disclosed herein are methods for determining whether a subject possesses altered pain sensitivity an altered risk of developing acute or chronic pain, or diagnosing a tetrahydrobiopterin (BH4)-related disorder or a propensity thereto. These methods are based on the discovery of GCH1 and KCNS1 allelic variants that are associated with altered pain sensitivity and altered risk of developing acute or chronic pain, and the discovery that a GCH1 "pain protective haplotype" is associated with decreased upregulation of BH4 synthesis in treated leukocytes.
申请公布号
EP1954832(A4)
申请公布日期
2009.10.28
申请号
EP20060836432
申请日期
2006.10.20
申请人
THE GENERAL HOSPITAL CORPORATION;NATIONAL INSTITUTES OF HEALTH