发明名称 |
PATTERNED CELL NETWORK SUBSTRATE INTERFACE AND METHODS AND USES THEREOF |
摘要 |
<p>There is provided herein a method and apparatus suitable for use in studying cell membrane related activities. Activities of interest include patch-clamp related studies of networks of cells on a solid substrate. Cells are grown, preferably in a patterned manner, on a substrate having microholes therein. Seals between the cells and the microholes are formed. Each microhole is attached to a channel. In many cases only one hole will be attached to a single channel, allowing examination of effects of a stimulus at a number of different points in a network of one or more cell types. This may be interest, for example, to those wishing to study interactions between neurons or neuromuscular junctions.</p> |
申请公布号 |
EP1751267(A4) |
申请公布日期 |
2009.10.28 |
申请号 |
EP20050741336 |
申请日期 |
2005.05.05 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
MEALING, GEOFFREY;PY, CHRISTOPHE;DENHOFF, MIKE;DOWLATSHAHI, REZA;FAID, KARIM;VOICU, RALUCA;BANI, MAHMUD |
分类号 |
C12M3/04;C12M1/14;C12M1/34;C12N5/00;C12Q1/02;G01N33/50 |
主分类号 |
C12M3/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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