PURPOSE: A cell permeable creatine kinase fusion protein is provided to effectively treat epilepsy, Alzheimer disease, Parkinson disease and heart disease. CONSTITUTION: A cell permeable creatine kinase fusion protein is bound with a transport domain at the end of one side of creatine kinase by covalent bond. The transport domain comprises 9 to 15 of amino acid residues. The transport domain contains 3/4 or more of arginine or lysine residue. The transport domain is HIV Tat 49-57 residue, oligolysine, oligoarginine or oligo. The fusion protein has an amino acid of the sequence number 7.
申请公布号
KR20090111894(A)
申请公布日期
2009.10.28
申请号
KR20080037494
申请日期
2008.04.23
申请人
INDUSTRY ACADEMIC COOPERATION FOUNDATION, HALLYM UNIVERSITY
发明人
CHOI, SU YOUNG;KIM, DAE WON;JANG, SANG HO;CHOI, JIN HEE;UM, WON SIK;KANG, TAE CHUN;KWON, OH SHIN;PARK, JIN SEO