Hybrid H1 Promoter for shRNA Expression

摘要

The invention provides a hybrid H1RNA gene promoter comprising a proximal sequence element (PSE) derived from the H1RNA gene promoter and a heterologuous distal sequence element (DSE), constructs for the expression of short nucleic acid sequences, such as shRNA, containing such a hybrid promoter, as well as biological entities containing such a hybrid promoter or such nucleic acid expression construct.