发明名称 |
NONHUMAN ANIMALS FOR ANTIBODY PRODUCTION, AND METHODS AND SYSTEMS FOR PRODUCING ANTIBODIES USING SUCH ANIMALS |
摘要 |
Membrane proteins that are background antigens were solubilized, and transgenic animals were produced using genes encoding these soluble proteins. Antibodies against the background antigen membrane proteins comprised in the immunogens were not found in these transgenic animals, and even when genes encoding soluble proteins were used, immunotolerance against the full-length membrane proteins could be induced. Moreover, by expressing the background antigen membrane proteins as soluble proteins inside the bodies of transgenic animals, unfavorable phenotypes that appear when the full-length membrane proteins are expressed could be avoided, and such animals were made widely available as immunized animals. |
申请公布号 |
EP1731032(A4) |
申请公布日期 |
2009.10.28 |
申请号 |
EP20050727975 |
申请日期 |
2005.03.31 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
KODAMA, TATSUHIKO;YAMADA, YOSHIKI;KAMADA, NOBUO;JISHAGE, KOU-ICHI |
分类号 |
A01K67/027;C07K16/00;C07K16/18;C12N15/09;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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