发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF EG5 GENE |
摘要 |
<p>The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Eg5 gene (Eg5 gene), comprising an antisense strand having a nucleotide sequence which is less than 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the Eg5 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Eg5 expression and the expression of the Eg5 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Eg5 gene in a cell.</p> |
申请公布号 |
EP2008274(A4) |
申请公布日期 |
2009.10.28 |
申请号 |
EP20070759825 |
申请日期 |
2007.03.30 |
申请人 |
ALNYLAM PHARMACEUTICALS INC. |
发明人 |
BUMCROT, DAVID;TAN, PAMELA;VORNLOCHER, HANS-PETER;GEICK, ANKE |
分类号 |
C07H21/02;A01N43/04;A61K31/70;C07H21/04;C12N15/113 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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