Method of screening candidate compounds for susceptibility to biliary excretion

摘要

The present inventions discloses a method of screening a candidate compound for susceptibility to biliary excretion, the method comprising the steps of providing a culture of hepatocytes, the culture of hepatocytes comprising at least one bile canaliculus, exposing a candidate compound to the culture, and determining an amount of candidate compound in the at least one bile canaliculus, the amount of the candidate compound in the at least one bile canaliculus indicating the susceptibility of the candidate compound to biliary excretion.