发明名称 |
Intracellular antibodies |
摘要 |
A method of identifying at least one consensus sequence for an intracellular antibody (ICS) comprising the steps of: creating a database comprising sequences of validated intracellular antibodies (VIDA database) and aligning the sequences of validated intracellular antibodies according to Kabat; determining the frequency with which a particular amino acid occurs in each of the positions of the aligned antibodies; selecting a frequency threshold value (LP or consensus threshold) in the range from 70% to 100%; identifying the positions of the alignment at which the frequency of a particular amino acid is greater than or equal to the LP value; and identifying the most frequent amino acid, in the position of said alignment.
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申请公布号 |
US7608453(B2) |
申请公布日期 |
2009.10.27 |
申请号 |
US20040771257 |
申请日期 |
2004.02.03 |
申请人 |
MRC SISSA-SCUOLA INTERNAZIONALE SUPERIORE DE STUDI AVANZATI |
发明人 |
CATTANEO ANTONINO;MARITAN AMOS;VISINTIN MICHELA;RABBITTS TERRENCE;SETTANNI GIOVANNI |
分类号 |
A61K51/00;C07K16/18;A61M36/14;C07K16/00;C12N5/06;C12N5/16;G01N33/48;G01N33/68;G06F17/00;G06F19/22 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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