发明名称 |
Pulse-medium perfusion bioreactor with improved mass transport for multiple-3-D cell constructs |
摘要 |
Disclosed is a novel net member for supporting one or more cell constructs in the culture chamber of a bioreactor, which comprises an array of impermeable pyramidal elements protruding from the face thereof, wherein each of the corners of the base of each of said impermeable pyramidal elements comprises a circular opening. This net member provides for uniform and unobstructed flow of culture medium through 3D cell constructs in culture. Also disclosed are a bioreactor and bioreactor system incorporating said net member. The bioreactor and bioreactor system may be used in the bioproduction of therapeutic proteins and stem cell expansion.
|
申请公布号 |
US7608447(B2) |
申请公布日期 |
2009.10.27 |
申请号 |
US20040581848 |
申请日期 |
2004.12.09 |
申请人 |
BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY |
发明人 |
COHEN SMADAR;DVIR TAL;SHACHAR MICHAL |
分类号 |
C12M1/00;C12M3/00 |
主分类号 |
C12M1/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|