| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention concerns photodynamic therapy (PDT) and claims composition with low concentration of hydrophobic photosensibilisers (PS) and improved method of PDT. In the claimed composition, given PS, meta-tetrahydroxyphenylchlorine (m-THPC) is present in concentration of 0.8 mg/ml to 0.04 mg/ml in the mix of pure ethyleneglycol and ethanol at 3:2 ratio. Composition reduces therapeutic effect accumulation time for the PS in affected tissue and time of achieving sufficient PS ratio in comparison to healthy tissue. Application of composition with m-THPC PS reduces interval between PS application/injection and irradiation. PS diffusion between affected and normal tissues can proceed fast enough for introduction in 'one day' or one night time. Claimed composition can be applied for PDT regimens where photosensibilisers are introduced in at least one prearranged dosage, including low-concentration therapy for PDT. ^ EFFECT: enhanced precision, effect and convenience dosage due to application of the claimed composition with low concentration in PDT. ^ 7 cl, 2 ex, 4 tbl |
