发明名称 |
PROCESS FOR THE PREPARATION OF (3-CYANO-1H-INDOL-7-YL)(4-(4-FLUOROPHENETHYL)PIPERAZIN-1-YL)-METHANONE AND SALTS THEREOF |
摘要 |
The present invention relates to a process for the preparation of (3-cyano-1 H- indol-7-yl)[4-(4-fluorophenethyl)piperazin-1-yl]-methanone and salts thereof , characterised in that an indole ester of the formula II in which R is as defined in Claim 1, is converter into 3-cyano-1H-indole-7-carboxylic acid vi a steps (1) to (4) according to Claim 1, and this is reacted with 1-[2-(4- fluorophenyl)ethyl]piperazine of salts thereof to give the product.
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申请公布号 |
CA2435426(C) |
申请公布日期 |
2009.10.27 |
申请号 |
CA20012435426 |
申请日期 |
2001.12.21 |
申请人 |
MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG |
发明人 |
CRASSIER, HELENE;BATHE, ANDREAS;EMMERT, STEFFEN;BOTTCHER, HENNING;ECKERT, UWE |
分类号 |
A61K31/496;C07D211/78;A61P1/14;A61P7/02;A61P9/00;A61P9/06;A61P25/00;A61P25/04;A61P25/20;A61P25/22;A61P25/30;A61P27/06;A61P39/02;A61P43/00;C07D209/14;C07D209/30;C07D209/42;C07D211/72 |
主分类号 |
A61K31/496 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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