发明名称 |
PREPARATION OF IRBESARTAN |
摘要 |
<p>The present invention relates to a process for the preparation of irbesartan or its pharmaceutically acceptable salts comprising a synthesis of trityl irbesartan by a reaction of 5-(4-(bromomethyl)biphenyl-2-yl)-l-(triphenylmethyl)tetrazole and 2-n-butyl-4-cyclopentane-2-imidazolin-5-one or a salt therof in an organic solvent in the presence of a phase transfer catalyst and a base, a removal of the protecting group and an isolation of irbesartan or its pharmaceutically acceptable salt.</p> |
申请公布号 |
UA88501(C2) |
申请公布日期 |
2009.10.26 |
申请号 |
UA20070008937 |
申请日期 |
2006.01.04 |
申请人 |
KRKA, TOVARNA ZDRAVIL, D.D. NOVO MESTO |
发明人 |
ZUPANCIC SILVO;PECAVAR ANICA;ZUPET ROK |
分类号 |
C07D403/10 |
主分类号 |
C07D403/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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