QUINOLONE DERIVATIVE AND USE THEREOF

摘要

Disclosed is a compound having excellent NK2 receptor binding activity. The compound is satisfactory as a pharmaceutical product. Specifically disclosed is a neurokinin receptor antagonist containing a compound represented by formula (I) or a salt thereof. In formula (I), --- represents a single bond or a double bond; A1 and A2 may be the same or different, and each represents an optionally substituted aromatic group; ring B represents an optionally substituted phenyl group; R represents a hydrogen atom or an optionally substituted hydrocarbon group; R1 may not exist, or represents a hydrogen atom, an optionally substituted alkyl group or an optionally esterified carboxyl group; X1 represents an optionally substituted methylene group; X2 represents an optionally substituted ethylene group; and Y represents an optionally substituted carbon atom, an optionally substituted nitrogen atom, an oxygen atom, or an optionally oxidized sulfur atom.