METHOD OF PRODUCING THROMBIN-IMMOBILIZED BIOABSORBABLE SHEET PREPARATION

摘要

Provided is a method of producing a bioabsorbable sheet preparation which comprises thrombin having been immobilized thereon. A method of producing a thrombin-immobilized bioabsorbable sheet preparation which comprises steps of dipping a bioabsorbable sheet comprising polyglycolic acid in a filling solution containing thrombin as the active ingredient, glycerol as a softening agent and Tween 80 as an infiltrating agent, optionally together with histidine and trehalose as stabilizers, drying the same and thus immobilizing thrombin on the bioabsorbable sheet as described above; and a thrombin-immobilized bioabsorbable sheet preparation obtained by the preceding method.